So... I was beating up the gate conductor that leads out of the Mongo River docks (lets face it, they're annoying). I punched him all the way down the tunnel. Satisfied, I bagged that bounty where you have to shoot the guy's back and saved. Big mistake, because the conductor wasn't there when I returned. The game locked him out of the gate, and I couldn't proceed! Either that or I murdered him... I reset the game and nothing happened. I had to restart my entire save file!